While the evidence supporting many interactions with psilocybin is limited, it is growing rapidly. Some interactions have stronger and better-quality evidence than others. When the risk of a medication’s use with psilocybin appears more likely and/or serious, we estimate the overall interaction risk to be “moderate”, “moderate to high” or “high”. Any “low” or “low to moderate” risk estimate indicates no interactions are identified or expected; or interactions are not considered serious; or they are potentially serious but uncommon/rare.
Please note reported interactions, like all drug interactions, are not guaranteed to happen, nor do they never happen. They are predicted possibilities which can be impacted by additional risk factors and context of use, and they can change based on available clinical evidence and pharmacology data.